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Quality of Life, Cognition and Toxicity

D. Steinmann et al. Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases. BMC Cancer. 2012; 12: 283. (free full text)

K. Komosinska et al Prospective Evaluation of the Palliative Effect of Whole-Brain Radiotherapy in Patients with Brain Metastases and Poor Performance Status Acta Oncologica 2010(44)382-388 (free full text)

J. Marsh et al Intracranial Metastatic Disease Spares The Limbic Circuit: A Review of 697 Metastatic Lesions in 107 Patients International Journal of Radiation Oncology Biology Physics 2010 (76) 2:504-512

N. Marko and R Weill Neurocognitive Considerations in the Treatment of Brain Metastases Nature Reviews Clinical Oncology April 2010 (7)185-186 (free full text)

K. Gehring et al Interventions for Cognitive Deficits in Patients with a Brain Tumor: an Update Expert Review of Anticancer Therapy 2010 10(11)1779-1795 (free full text)

S. Wong Goodrich et al Voluntary Running Prevents Progressive Memory Decline and Increases Adult Hippocampal Neurogenesis and Growth Factor Expression after Whole-Brain Irradiation Cancer Research Therapeutics, Targets and Chemical Biology Nov 15, 2010: 70(22) 

S. Gripp et al  Palliative Radiotherapy Tailored to Life Expectancy in End-Stage Cancer Patients: Reality or Myth? Cancer Jul 1 2010 116(13) 3251-6

J. Marsh et al  Cognitive Sparing during the Administration of Whole Brain Radiotherapy and Prophylactic Cranial Irradiation: Current Concepts and Approaches  Journal Oncol June 27 2010 (free full text)

F. Nicholas et al  Neurocognitive Considerations in Treatment of Brain Metastases Nat Rev Clin Onc April 8 2010 &(4):185-186 (free full text)

A. Hird  Exploration of Symptoms Clusters Within Cancer Patients with Brain Metastases Using the Spitzer Quality of Life Index  Support Care Cancer Mar 2010 18(3):335-42

P. Feyer et al   DEGRO Practical Guidelines for Palliative Radiotherapy of Breast Cancer Patients: Brain Metastases and Leptomeningeal Carcinomatosis  Strahlenther Onkologie Feb 2010 186(2):63-9

J. Marsh et all  Intracranial Metastatic Disease Spares the Limbic Circuit: A Review of 697 Metastatic Lesions in 107 Patients  Int J Radiat Oncol Biol Phys Feb 1 2010 76(2):504-12

E Chang et al Neurocognition in Patients with Brain Metastases Treated with Radiosurgery plus Radiosurgery or Radiosurgery plus Whole-Brain Radiosurgery Irradiation: A Randomized Controlled Trial Lancet Oncology 2009 (10)1037-1044 (free full text)

Wong J. et al  Symptoms and Quality of Life in Cancer Patients with Brain Metastases Following Palliative Radiotherapy  International Journal of Radiation Oncology Biology  Physics Nov 15 2009 75(4):1125-31

E. Chang et al Neurocognition in Patients with Brain Metastases Treated with Radiosurgery or Radiosurgery plus Whole-Brain Irradiation: A Randomised Controlled Trial. Lancet Oncol 2009 (1) 1037-1044

G. Welzel et al  Acute Neurocognitive Impairment During Cranial Radiation Therapy in Patients with Intracranial Tumors Strahlenther Onkol Dec 2008 184(12):647-54

A. Sturdza, B. Millar A. Bezjak et al The Use and Toxicity of Steroids in the Mamagement of Patients with Brain Metastases   Supportive Care in Cancer, Sept. 2008; 16 (9)

G.Welzel, K. Fleckenstein, F. Wenz et al Memory Function Before and After Whole Brain Radiotherapy in Patients with and Without Brain Metastases   International  Journal of Radiation Oncology Biology Physics, March 9, 2008; 1-8

J. Li, M. Soren, M. Mehta et al Regression After Whole-Brain Radiation Therapy for Brain Metastases Correlates with Survival and Improved Neurocognitive Function Journal of Clinical Oncology, April 1, 2007; 25 (10): 1260-1266  

J. Varlotto, J. Flickinger, L. Lunsford et al The Impact of Whole-Brain Radiation Therapy on the Long-Term Control and Morbidity of Patients Surviving More than One Year After Gamma Knife Radiosurgery for Brain Metastases   International Journal of Radiation Oncology Biology Physics, 2005; 62 (40): 971-977

D. Rades,  G. Bohlen, and A. Pluemer Stereotactic Radiosurgery Alone versus Resection Plus Whole-Brain Radiation for 1 or 2 Brain Metastases in Recursive Partitioning class 1 and 2.  Cancer, June 15; 100 (12) 2515-2521.

J. Li, S. Rentzen, and M. Renschler et al  Regression After Whole-Brain Radiation Therapy for Brain Metastases Correlates with Survival and Improved Neurocognitive Function. Journal of Clinical Oncology, April 1, 2007; 25 (10): 1260-1266. (free full text)

M. Doyle, N. Bradley, K. Li et al Quality of Life in Patients with Brain Metastases Treated with a Palliative Course of Whole-Brain Radiation. Journal of Palliative Medicine, April 2007; 10 (20): 367-374.

E. Chang, J. Wefel, M. Maor et al A Pilot Study of Neurocognitive Function in Patients with One to Three New Brain Metastases Initially Treated With Stereotactic Radiosurgery Alone. Neurosurgery, February 2007; 60 (2): 277-283; discussion 243-284. 

M. Yaneva and M. Semerdijleva Assessment of the Effect of Palliative Radiotherapy for Cancer Patients with Intracranial Metastases Using EORTC-QOL-C30 Questions. Folia Med  2006; 48 (2) 23-29.

L. Kleinberg, J. Wefel, and W. Regine Should Whole-Brain Radiation Therapy Follow Focal Therapy of a Single and Multiple Brain Metastasis? 2006; ASCO Education Session (4 presentations, with audio and slides).

E. Chow, L. Davis, L. Holden et al  Prospective Assessment of Patient-Rated Symptoms Following Whole-Brain Radiotherapy for Brain Metastases Journal Pain Symptom Management , July 2005; 30 (1): 18-23.

J. Varlotto, J. Flickinger, A. Niranjan et al  The Impact of Whole-Brain Radiation Therapy on the Long-Term Control and Morbidity of Patients Surviving More than One Year After Gamma Knife Radiosurgery for Brain Metastases International Journal of Radiation Oncology (Biology Physics), July 15, 2005; 62 (4): 1125-1132.

A. Bhatnager, J. Flickinger, D. Kondziolka et al  Stereotactic Radiosurgery for Four or More Intracranial Metastases. International Journal of Radiation Oncology (Biology Physics) 2003; 23: 269-270.

G. Batel, L. Kleinberg, and S. Terezakis Current Concepts and Controversies in the Treatment of Parenchymal Brain Metastases: Improved Outcomes with Aggressive Management. Cancer Investigation. 2005; 23 (4): 363-376.

J. Varlotto, J. Flickinger, A. Niranjan et al Analysis of Tumor Control and Toxicity in Patients Who Have Survived at Least One Year After Radiosurgery for Brain Metastases. International Journal of Radiation of Oncology (Biology Physics). October 1, 2003; 57 (2): 452-464.

G. Gerrard, R. Prestwich, A. Edwards et al  Investigating the Palliative Efficacy of Whole-Brain Radiotherapy for Patients with Multiple-brain Metastases and Poor Prognosis Features. Clinical Oncology (R Coll Radiol) October 2003; 15 (7): 422-428.

M. Tsao, K. Sultanem, D. Chiu et al Supportive Care Management of Brain Metastases: What is Known and What We Need to Know. Conference Proceedings of the National Caner Institute of Canada, Workshop on Symptoms Control in Radiation Oncology. Clinical Oncology (R Coll Radiol) October 2003; 15 (7): 429-434.

M. Chidal, J. Suh, C. Reddy et al Application of Recursive Partitioning Analysis and Evaluation of the Use of Whole- Brain Radiation Among Patients Treated with Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases International Journal of Radiation Oncology (Biology Physics) July 1, 2000; 47 (4): 993-999.

R. Crossen, D. Garwood, E. Neuwelt  Neurobehavioral Sequelase of Cranial Irridation in Adults: A Review of Radiation-Induced Encephalopathy.  Journal of Clinical Oncology. March 1994; 12 (3): 622-627