Early Detection and Prevention of Brain Metastases

P. Canney et al.  A Prospective Randomised Phase lll Clinical Trial Testing the Role of Prophylactic Cranial Radiotherapy in Patients Treated with Trastuzumab (Herecptin) for Metastatic Breast Cancer-Anglo Celtic Vll  Clin Oncol (R Coll Radiol)  2015 Aug;27(8):460-4. (NOTE: this trial was not large enough to prove that cranial radiotherapy actually prevented brain metastasis.  With small numbers, the apparent trial benefit could have occurred by chance)

Y. Keinast  Therapy and Prophylaxis of Brain Metastases  Expert Review of Anticancer Therapy  Nov 2010 10(11):1763-77

O. Graesslin et al  Nomogram to Predict Subsequent Brain Metastasis in Patients with Metastatic Breast Cancer  Journal of Clinical Oncology April 20 2010 28(12):2032-7

K. Miller, T. Weathers, L. Haney et al  Occult Central Nervous System Involvement in Patients with Metastatic Breast Cancer: Prevalence, Predictive Factors and Impact on Overall Survival Annals of Oncology, 14:1072-1077, 2003 (free full text).

R. Soffiett et al  The Role of Intra-Cerebrospinal Fluid Treatment and Prophylaxis in Patients with Solid Tumors  Seminal Oncology Aug 2009 36 (4 Suppl 2):S55-68

J. Huang et al  Prophylactic Cranial Irradiation in Advanced Breast Cancer: a Case for Caution  International Journal of Radiation Oncology Biology and Physics Mar 1 2009 73(30):75

D. Kirsch and J. Loeffler Brain Metastases in Patients with Breast Cancer: New Horizons Clinical Breast Cancer, 2005; 6 (2): 115-124.