HER2-Positive Breast Cancer Brain Mets

J. Miller, et al . Overall Survival and the Responses to Radiotherapy among Molecular Subtypes of Breast Cancer Brain Metastases Treated with Targeted Therapies   Cancer; Feb 13 2017

N. Senda et al.  Pertuzumab (Perjeta), Trastuzumab (Herceptin) and Docetaxel (Taxotere) Reduced the Recurrence of Brain Metastasis from Breast Cancer: A Case Report.  Breast Cancer, 2016;Mar 23(2):323-8

Zhang Q et al.  Survival Benefit of Anti HER-2 Therapy After Whole-Brain Radiotherapy in HER 2-positive Breast Cancer Patients with Brain Metastasis. Breast Cancer. 2015 Aug 13.

I.E. Krop et al. Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA. Ann Oncol. 2015 Jan;26(1):113-9. 

I. E. Krop et al.  A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine.  J Clin Oncol. 2012 Sep 10;30(26):3234-41  (For free full text of study on which the above analysis was based).

E. Teplinsky, F.J. Esteva Systemic Therapy for HER2-Positive Central Nervous System Disease: Where We Are and Where Do We Go From Here? Curr Oncol Rep. 2015 Oct;17(10):46

E. Bergen, R. Bartsch  Breast Cancer Brain Metastases Responding to Lapatinib plus Capecitabine as Second-line Primary Systemic Therapy  Anticancer Drugs   2015;vol 26 no 5  :579-81

A. Patil and G. Sherbet    Therapeutic Approach to the Management of Her2-positive Breast Cancer Metastatic to the Brain Cancer Letters   2015;358 (2):162-163 

G. Ricciardi et al  Efficacy of Nab-paclitaxel plus Trastuzumab in a Long-Surviving Heavily Pretreated Her2-positive Breast Cancer Patients with Brain Metastases  Onco Targets Ther   April 15  2015;vol 15 no 2   8:289-94 PMID25678799 (free full text)
R. Kalsi et al  Brain Metastasis and Response to Ado-Trastuzumab Emtansine: A Case Report and Literature Review Clinical Breast Cancer Oct 19 2014;s1526-8209(14)00223-7 PMID25454740
S. Torres et al  Activity of T-DM1 in Her-2 positive Central Nervous System Breast Cancer Metastases British Medical Journal (BMJ Case Rep) Aug 14;2014
C Helwick   How to Approach the Problem of CNS Metastasis in Her2-positive Patients The ASCO Post March 15, 2014;Vol 5 Issue 5 (free full text) 
R. Bartsch et al  T-DM1 in Her2-Positive Breast Cancer Brain Metastases  J Clin Oncol 2014;32:5s(suppl abstract 650) 

T. Bachelot et al  Lapatinib plus Capecitabine in Patients with Previously Untreated Brain Metastases from Her2-positive Metastatic Breast Cancer (LANSCAPE): A  Single-Group Phase 2 Study  Lancet Oncol Jan 2013; 14(1):64-77 

M. Bartolotti et al  Treatment of Brain Metastases from HER2-Positive Breast Cancer: Current Status and New Concepts  Future Oncol 2013 Nov;9(11):1653-64

P. Larsen et al  A Systematic Review of Trastuzumab and Lapatinib in the Treatment of Women with Brain Metastases from HER2-Positive Breast Cancer  Cancer Treat Rev 2013 Nov;39(7):720-727

N. Lin et al  A Phase I Study of Lapatinib with Whole Brain Radiotherapy in Patient with Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Brain Metastases  Breast Can Res Treatment 2013 Nov 7 (Epub ahead of print)

E. Oktay et al  Nearly Complete Response of Brain Metastases from HER2 Overespressing Breast Cancer with Lapatinib and Capecitabine after Whole Brain Irradiation  Case Rep Oncol Med Epub 2013 Sept 26 (full text)

R. Bartsch et al  Breast Cancer Brain Metastases Responding to Primary Systemic Therapy with T-DM1 J Neurooncol 2013 Sept 25 (Epub ahead of Print)

H. Iwata et al  A Phase ll Study of Lapatinib for Brain Metastases in Patients with HER2- Overexpressing Breast Cancer Following Trastuumab Based System Therapy and Cranial Radiotherapy: Subset Analysis of Japanese Patients  Int J Clin Oncol 2013 Aug;18(4):621-8

A. Chien and H. Rugo  Emerging Treatment Options for the Manangement of Brain Metastases in Patients with HER2-positive Metastatic Breast Cancer  Breast Cancer Res Treat 2013 Jan;137(1):1-12

D. Kodack et al  Combined Targeting of HER2 and VEGFR2 for Effective Treatment of HER2-Amplified Breast Cancer Brain Metastases  Proceedings of the National Academy of Science USA  2012 Nov 6: 109(45) Epub Oct. 15 (full text)

R. Duchnowska et al  Conversion of Epidermal Growth Factor Receptor 2 and Hormone Receptor Expression in Breast Cancer Metastases to the Brain  Breast Cancer Res 2012 Aug 16:14(4)

C. Neider  Radiotherapy and the Re-irradiation of Breast Cancer Patients with Brain Metastases: Survival in the Trastuzumab Era  Strahlenther Onkol 2012 July 188(7):638-39 (Article in German)

R. Duchnowska et at   Correlation Between Quantitative Her-2 Protein Expression and Risk for Brain Metastases in Her-2 Advanced Breast Cancer Patients Receiving Trastuzumab-Containing Therapy   The Oncologist 2012 17:26-35 online here

YS. Yap et al   Brain Metastases in Asian Her-2 Positive Breast Cancer Patients: Anti-HER2 Treatments and Their Impact on Survival   British Journal of Cancer 2012 107:1085-1077

J. Ro et al   Clinical Outcomes of HER2-Positive metastatic breast cancer Patients with Brain Metastasis Treated with Lapatinib and Capecitabine: an Open-Label Expanded Access Study in Korea   Biomedcentral Central Cancer 2012 12:332  

A. Mehta et al   Therapeutic Approaches for HER2-Positive Brain Metastases: Circumventing the Blood-Brain Barrier  Cancer Treatment Review 2012 

S. Sutherland et al Treatment of HER2-Positive Metastatic Breast Cancer with Lapatinib and Capecitabine in the Lapatinib Expanded Access Programe, including Efficacy in Brain Metastases-the UK Experience British Journal of Cancer  2010 (102):995-102

M. Abboud et al Complete Response of Brain Metastases from Breast Cancer Overexpressing Her-2/neu to Radiation and Concurrent Lapatinib and Capecitabine The Breast Journal 2010 Vol.16:6 

A. Braen A 4-Week Intrathecal Toxicity and Pharmacokinetic Study in Cynomolgus Monkeys International Journal Toxicology May 2010 29(3):259-67

T. Pienkowski et al  Trastuzumab (Herceptin) Treatment in Patients with Breast Cancer and Metastatic CNS Disease  Annals of Oncology May 2010 21(5):917-24

S Dawood et al  Prognostic Factor of Survival in the Trastuzumab (Herceptin) Era among Women with Breast Cancer amd Brain Metastases who Receive Whole Brain Radiotherapy: a Single-insitution Review  Cancer Jul 1 2010 116(13):3084-92

A. Niwinska et al The Effect of Early Detection of Occult Brain Metastases in HER2-positive Breast Cancer Patients on Survival and Cause of Death  International Journal of Radiation Oncology Biology Physics  Jul 15 2010 77(4):1134-9

G. Tomasello et al Brain Metastases in HER2-positive Breast Cancer: the Evolving Role of Lapatinib (Tykerb)  Critical Review of Oncology Hematology  Aug 2010 75(20):110-21

G. Metro et al   Clinical Outcome of Patients with Brain Metastases from Her2-Positive Breast Cancer treated with Lapatinib (Tykerb) and Capecitabine (Xeloda) Annals of Oncology Aug 19 2010

S. Sutherland et al  Treatment of HER-2 Positive Metastatic Breast Cancer with Lapatinib and Capecitabine in the Lapatinib (Tykerb) Expanded Access Programme, Including Efficacy in Brain Metastases-the UK Experience  British Journal Cancer Mar 16 2010 102(6): 995=1002

M. Melisko  New Challenges and Opportunities in the Management of Brain Metastases in Patients with Erb2-Positive Metastatic Breast  Cancer  Nat Clin Pract Oncol Jan 2009 6(1):25-33

B. Pestalozzi Brain Metastases and subtypes of Breast Cancer  Annals of Oncology April 2009 20(4): 803-5  FREE FULL TEXT

M. Colozza et al Extended Survival of a Her-2 Positive Metastatic Breast Cancer Patient with Brian metastatses also Treated with Intrathecal Trastuzumab (Herceptin)  Cancer Chemothery Pharmacol May 2009 63(6):1157-9

B. Leyland-Jones  Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Central Nervous systems Metastases  Journal of Clinical Oncology Nov 2009 27(31):5278-86

H. Stemmler, K Mengele, V. Heinemann Intrathecal Trastuzumab (Herceptin) and Methotrexate for Meningeal Carcinomatosis in HER2-Overexpressing Metastatic Breast Cancer: A Case Report   Anti Cancer Drugs,  2008; 19:832-836

B. Nam, S. Kim, J. Ro et al Breast Cancer Subtypes and Survival in Patients with Brain Metastases   Breast Cancer Research, Feb. 28, 2008

A. Eichler, I. Kuter, J. Henson et al Survival in Patients With Brain Metastases From Breast Cancer: The Importance of HER-2 Status  Cancer   March 2008

M. Melisko, D. Moore, H. Rugo et al Brain Metastases in Breast Cancer: Clinical and Pathologic Characteristics Associated with Improvements in Survival   Journal of Neurooncology. 2008; 88:359-365

I. Park, J. Ro, B. Nam et al Trastuzumab Treatment Beyond Brain Progression in HER2-Positive Metastatic Breast Cancer   Annals of Oncology. July 2008 (Epub ahead of print) 

S. Fromm, R. Bartsch, K. Dieckmann et al  Factors Influencing the Time to Development of Brain Metastases in Breast Cancer   The Breast,  2008; 1-5

R. Bartsch, A. Rottenfusser, G. Steger et al Trastuzumab Prolongs Overall Survival in Patients with Brain Metastases from Her2 Positive Breast Cancer   Journal of Neurooncology, 2007; 85:311-317

Y. Than, K. Sexton, R. Elledge et al Primary Breast Cancer Phenotypes Associated with Propensity for Central Nervous System Metastases   Cancer,  July 2006

D. Hicks, S. Short, R. Weill et al  Breast Cancers with Brain Metastases are More Likely to be Estrogen Receptor Negative, Express the Basal Cytokeratin CK5/6, and Overexpress Her2 or EGFR   American Journal of Surgery and Pathology, Sept. 26, 2006; 30:9 

S. Gori, S. Rimondini, V. De Angelis et al Central Nervous System Metastases in HER2-Positive Metastatic Breast Cancer Patients Treated with Trastuzumab: Incidence, Survival, and Risk Factors The Oncologist, July 2007; 12 (7): 766-773 (free full text).

N. Lin and E. Winer Brain Metastases: The HER2 Paradigm Clinical Cancer Research, March 15, 2007; 13 (6).

Z. Gambos, R. Sinha, J. Hanson et al Prognostic Significance of Human Epidermal Growth Factor Receptor Positivity for the Development of Brain Metastasis after Newly Diagnosed Breast Cancer Journal of Clinical Oncology, December 20, 2006; 24 (36): 5658-5663.

D. Kirsch and J. Loeffler Survival after Brain Metastases from Breast Cancer in the Trastuzumab (Herceptin) Era Journal of Clinical Oncology,  March 20, 2005; 23 (9): 2114-2116 (free full text).

H. Burstein, G. Lieberman, D. Slamon et al Isolated Central Nervous System Metastases Treated with HER2-Overexpressing Advanced Breast Cancer Treated with First-line Trastuzumab (Herceptin)-Based Therapy Annals of Oncology, September 8, 2005; 16: 1772-1777  (free full text).

A. Clayton, S. Danson, S. Jolly et al Incidence of Cerebral Metastases in Patients Treated with Trastuzumab (Herceptin) for Metastatic Breast Cancer British Journal of Cancer, July 20, 2004; 91: 649-643.

N. U. Lin, V. Dieras, D. Paul, D. Lossignol, C. Christodoulou, D. Laessig, H. Roché, D. Zembryki, C. R. Oliva, E. P. Winer, EGF105084 Study Group. EGF105084, a phase II study of lapatinib for brain metastases in patients (pts) with HER2+ breast cancer following trastuzumab (H) based systemic therapy and cranial radiotherapy (RT).  Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 1012 (Slide presentation online).

N. U. Lin, L. A. Carey, M. C. Liu, J. Younger, S. E. Come, E. Bullitt, A. D. Van Den Abbeele, X. Li, F. H. Hochberg, E. P. Winer. Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer.  Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 503. (Slide presentation online).

C.E. Geyer, J. Forster, D. Lindquist, et al. Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer. The New England Journal of Medicine, December 28, 2006, number 26, 355:2733-2743 (full text with free registration).